Daniel James keeps his place on the right wing, with Anthony Martial spearheading the attack and aiming to find the net for the third successive game. Aaron Wan-Bissaka starts, at right-back, against his former club.
The substitutes' bench that was selected on Monday night at Wolves is also retained.
Scott McTominay makes his 50th appearance in all competitions, since breaking into the team towards the end of the 2016/17 season.
It is also worth noting that Harry Maguire and Victor Lindelof continue their partnership in the centre of the defence, after a promising start while working in tandem.