The injuries suffered to Luke Shaw and Anthony Martial in that clash means the boss was always going to be forced to shuffle the pack for our trip to the south coast.
In their place, Ole has selected Ashley Young - who captains the side - and Andreas Pereira, who scored a spectacular goal against Southampton at Old Trafford last season.
The other change from last weekend’s side sees Juan Mata come in for Jesse Lingard, who is named on the bench.
Speaking to MUTV before the game, Ole said: “Luke and Anthony are injured so Ash is an easy decision in there.